Reducing the mystery of neuronal differentiation
- PMID: 19766560
- DOI: 10.1016/j.cell.2009.09.001
Reducing the mystery of neuronal differentiation
Abstract
In the developing nervous system, neural progenitors exit the cell cycle and differentiate on a precise schedule, yet the mechanisms driving this process remain poorly defined. Yan et al. (2009) now identify a thiol-redox reaction mediated by the membrane protein GDE2 and the peroxiredoxin protein Prdx1 that promotes neurogenesis.
Comment on
-
The antioxidant enzyme Prdx1 controls neuronal differentiation by thiol-redox-dependent activation of GDE2.Cell. 2009 Sep 18;138(6):1209-21. doi: 10.1016/j.cell.2009.06.042. Cell. 2009. PMID: 19766572 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Miscellaneous
