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. 2009 Oct;41(10):1116-21.
doi: 10.1038/ng.450. Epub 2009 Sep 20.

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Rosalind A Eeles  1 , Zsofia Kote-Jarai, Ali Amin Al Olama, Graham G Giles, Michelle Guy, Gianluca Severi, Kenneth Muir, John L Hopper, Brian E Henderson, Christopher A Haiman, Johanna Schleutker, Freddie C Hamdy, David E Neal, Jenny L Donovan, Janet L Stanford, Elaine A Ostrander, Sue A Ingles, Esther M John, Stephen N Thibodeau, Daniel Schaid, Jong Y Park, Amanda Spurdle, Judith Clements, Joanne L Dickinson, Christiane Maier, Walther Vogel, Thilo Dörk, Timothy R Rebbeck, Kathleen A Cooney, Lisa Cannon-Albright, Pierre O Chappuis, Pierre Hutter, Maurice Zeegers, Radka Kaneva, Hong-Wei Zhang, Yong-Jie Lu, William D Foulkes, Dallas R English, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Jonathan Morrison, Audrey T Ardern-Jones, Amanda L Hall, Lynne T O'Brien, Rosemary A Wilkinson, Edward J Saunders, Elizabeth C Page, Emma J Sawyer, Stephen M Edwards, David P Dearnaley, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Nicholas Van As, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Colin S Cooper, Melissa C Southey, Artitaya Lophatananon, Jo-Fen Liu, Laurence N Kolonel, Loic Le Marchand, Tiina Wahlfors, Teuvo L Tammela, Anssi Auvinen, Sarah J Lewis, Angela Cox, Liesel M FitzGerald, Joseph S Koopmeiners, Danielle M Karyadi, Erika M Kwon, Mariana C Stern, Roman Corral, Amit D Joshi, Ahva Shahabi, Shannon K McDonnell, Thomas A Sellers, Julio Pow-Sang, Suzanne Chambers, Joanne Aitken, R A Frank Gardiner, Jyotsna Batra, Mary Anne Kedda, Felicity Lose, Andrea Polanowski, Briony Patterson, Jürgen Serth, Andreas Meyer, Manuel Luedeke, Klara Stefflova, Anna M Ray, Ethan M Lange, Jim Farnham, Humera Khan, Chavdar Slavov, Atanaska Mitkova, Guangwen Cao; UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology; UK ProtecT Study Collaborators; PRACTICAL Consortium; Douglas F Easton
Collaborators, Affiliations

Identification of seven new prostate cancer susceptibility loci through a genome-wide association study

Rosalind A Eeles et al. Nat Genet. 2009 Oct.

Abstract

Prostate cancer (PrCa) is the most frequently diagnosed cancer in males in developed countries. To identify common PrCa susceptibility alleles, we previously conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 PrCa cases with clinically detected disease and in 1,894 controls. We have now extended the study to evaluate promising associations in a second stage in which we genotyped 43,671 SNPs in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies. In addition to replicating previous associations, we identified seven new prostate cancer susceptibility loci on chromosomes 2, 4, 8, 11 and 22 (with P = 1.6 x 10(-8) to P = 2.7 x 10(-33)).

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Competing Financial Interests

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Figures

Figure 1
Figure 1
Summary of experimental design and results. Numbers quoted are after QC (see Online Methods).
Figure 2
Figure 2
Forrest plots for the 12 SNPs replicated in stage 3. Squares represent the estimated per-allele odds ratio (OR) for each study. Lines indicate the 95% confidence interval. Diamonds represent the OR estimates and confidence limits for the subgroups indicated. The SNPs rs4782780 and rs11861609 are highly correlated and only one was typed in any study. The OR is shown for the SNP typed in each study (see Online Methods).
See this image and copyright information in PMC

References

    1. Eeles RA, et al. Multiple newly identified loci associated with prostate cancer susceptibility. Nat Genet. 2008;40:316–321. - PubMed
    1. Witte JS. Prostate cancer genomics: towards a new understanding. Nat Rev Genet. 2009;10:77–82. - PMC - PubMed
    1. Amundadottir LT, et al. A common variant associated with prostate cancer in European and African populations. Nat Genet. 2006;38:652–658. - PubMed
    1. Gudmundsson J, et al. Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24. Nat Genet. 2007;39:631–637. - PubMed
    1. Gudmundsson J, et al. Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes. Nat Genet. 2007;39:977–983. - PubMed

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