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Identification of a new prostate cancer susceptibility locus on chromosome 8q24

Meredith Yeager et al. Nat Genet. 2009 Oct.

Abstract

We report a genome-wide association study in 10,286 cases and 9,135 controls of European ancestry in the Cancer Genetic Markers of Susceptibility (CGEMS) initiative. We identify a new association with prostate cancer risk on chromosome 8q24 (rs620861, P = 1.3 x 10(-10), heterozygote OR = 1.17, 95% CI 1.10-1.24; homozygote OR = 1.33, 95% CI 1.21-1.45). This defines a new locus associated with prostate cancer susceptibility on 8q24.

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Figures

Figure 1
Figure 1. Linkage disequilibrium (LD) and Association Results for 82 SNPs Genotyped Over ∼314kb of Chromosome 8q24
SNPs included were tagged with r2 > 0.8 in HapMap CEU (build 26) or included in Stage 2 of CGEMS across the region defined for chr8:128,154,828 – 128,472,696. The LD shown was determined on the basis of the 9,135 control individuals.
See this image and copyright information in PMC

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