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Review
. 2009 Dec 17;583(24):3900-4.
doi: 10.1016/j.febslet.2009.09.031.

Metabolic systems biology

Bernhard Palsson  1
Affiliations
Review

Metabolic systems biology

Bernhard Palsson. FEBS Lett. .

Abstract

The first full genome sequences were established in the mid-1990s. Shortly thereafter, genome-scale metabolic network reconstructions appeared. Since that time, we have witnessed an exponential growth in their number and uses. Here I discuss, from a personal point of view, four topics: (1) the placement of metabolic systems biology in the context of broader scientific developments, (2) its foundational concepts, (3) some of its current uses, and (4) some of the expected future developments in the field.

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Figures

Figure 1
Figure 1
Growth of genome sequences and genome-scale metabolic reconstructions. The number of network reconstruction has grown exponentially, at a similar pace as genome sequences have appeared [Prepared by Adam Feist and Ines Thiele].
Figure 2
Figure 2
The four-step paradigm for metabolic systems biology. Adapted from [4]. Prepared by Adam Feist.
See this image and copyright information in PMC

References

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    1. Edwards JS, Palsson BO. Systems properties of the Haemophilus influenzae Rd metabolic genotype. Journal of Biological Chemistry. 1999;274:17410–6. - PubMed
    1. Edwards JS, Palsson BO. The Escherichia coli MG1655 in silico metabolic genotype: Its definition, characteristics, and capabilities. Proc Natl Acad Sci U S A. 2000;97:5528–5533. - PMC - PubMed
    1. Palsson BO. Systems biology: properties of reconstructed networks. Cambridge University Press; New York: 2006.
    1. Price ND, Reed JL, Palsson BO. Genome-scale models of microbial cells: evaluating the consequences of constraints. Nat Rev Microbiol. 2004;2:886–897. - PubMed

Publication types