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Review
. 2009 Dec;89(4):334-42.
doi: 10.1016/j.pneurobio.2009.09.002. Epub 2009 Sep 19.

Synaptic plasticity in the subiculum

Joachim Behr  1 , Christian Wozny, Pawel Fidzinski, Dietmar Schmitz
Affiliations
Review

Synaptic plasticity in the subiculum

Joachim Behr et al. Prog Neurobiol. 2009 Dec.

Abstract

The subiculum is the principal target of CA1 pyramidal cells. It functions as a mediator of hippocampal-cortical interaction and has been proposed to play an important role in the encoding and retrieval of long-term memory. The cellular mechanisms of memory formation are thought to include long-term potentiation (LTP) and depression (LTD) of synaptic strength. This review summarizes the contemporary knowledge of LTP and LTD at CA1-subiculum synapses. The observation that the underlying mechanisms of LTP and LTD at CA1-subiculum synapses correlate with the discharge properties of subicular pyramidal cell reveals a novel and intriguing mechanism of cell-specific consolidation of hippocampal output.

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