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. 1977 May;6(5):591-3.
doi: 10.1016/0091-3057(77)90122-8.

Use of DRL in differentiating anxiolytic and neuroleptic properties of CNS drugs

J G Canon, A S Lippa

Use of DRL in differentiating anxiolytic and neuroleptic properties of CNS drugs

J G Canon et al. Pharmacol Biochem Behav. 1977 May.

Abstract

Presented in this paper are the effects of chlorpromazine, clozapine, d-amphetamine and diazepam on DRL behavior in rats. D-Amphetamine and diazepam, which showed similar effects on response errors, could be identified on the basis of burst responding and drug interaction. Clozapine, a new antipsychotic agent which does not cause extrapyramidal side effect in man affected DRL behavior in the same way as did chlorpromazine. Thus, DRL schedules are probably not useful in differentiating various neuroleptic agents.

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