Immunosuppressive withanolides from Withania coagulans

Abstract

Six new withanolides, withacoagulins A-F (1-6, resp.), together with ten known withanolides, 7-16, were isolated from the aerial parts of Withania coagulans. Their structures were determined by spectroscopic techniques including 1D- and 2D-NMR (1H, 13C, HMQC, and HMBC) and MS experiments. These compounds, including the crude extracts of this herb, exhibited strong inhibitory activities on the T- and B-cell proliferation.