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. 1990;95(2):197-9.
doi: 10.1016/0742-8413(90)90103-g.

The cardiac effects of parathyroid hormone in the tiger frog, Rana tigrina

K W Chiu  1 , Y C Lee, P K Pang
Affiliations

The cardiac effects of parathyroid hormone in the tiger frog, Rana tigrina

K W Chiu et al. Comp Biochem Physiol C Comp Pharmacol Toxicol. 1990.

Abstract

1. The cardiac effects of the N-terminal (1-34) peptide fragment of bovine parathyroid hormone [bPTH-(1-34)] on isolated atria were examined in the frog, Rana tigrina. 2. bPTH-(1-34) produced dose-related inotropic response but no chronotropic response. This inotropic response varied at different times of the year. 3. The inotropic effect of bPTH-(1-34) was attenuated in the presence of verapamil and imidazole. 4. The mechanism of action of bPTH-(1-34) is probably a stimulation of calcium influx directly or indirectly via cAMP production.

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