doi: 10.1016/0922-4106(90)90237-r.
Caged ATP potentiates guanylate cyclase activity stimulated by atrial natriuretic factor in rat lung membranes
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- PMID: 1977602
- DOI: 10.1016/0922-4106(90)90237-r
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Caged ATP potentiates guanylate cyclase activity stimulated by atrial natriuretic factor in rat lung membranes
Eur J Pharmacol.
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Abstract
ATP increases both basal and atrial natriuretic factor (ANF)-stimulated guanylate cyclase activities. The present studies were designed to compare the effect of adenosine-5'-triphosphate, P3-1-(2-nitrophenyl)-ethyl ester (caged ATP), a photolabile derivative of ATP, with ATP. Caged ATP increases both basal and ANF-stimulated enzyme activities in a concentration-dependent manner, but is more potent than ATP. The effect of caged ATP significantly decreases after it is photo-converted to ATP by UV irradiation. These observations suggest that the caged group introduces a hydrophobic interaction thereby facilitating guanylate cyclase activation.
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