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. 2009 Sep;51(3):401-6.
doi: 10.2334/josnusd.51.401.

Antifungal activity of alpha-mangostin against Candida albicans

Ruchadaporn Kaomongkolgit  1 , Kusuma Jamdee, Niratcha Chaisomboon
Affiliations

Antifungal activity of alpha-mangostin against Candida albicans

Ruchadaporn Kaomongkolgit et al. J Oral Sci. 2009 Sep.

Abstract

This study was conducted to examine the activity of alpha-mangostin against Candida albicans, the most important microorganism implicated in oral candidiasis. Its activity was compared to Clotrimazole and Nystatin. Results showed that alpha-mangostin was effective against C. albicans, the minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) were 1,000 and 2,000 microg/ml, respectively. The C. albicans killing activity of alpha-mangostin was more effective than Clotrimazole and Nystatin. The cytotoxicity of alpha-mangostin was determined and it was found that alpha-mangostin at 4,000 microg/ml was not toxic to human gingival fibroblast for 480 min. The strong antifungal activity and low toxicity of alpha-mangostin make it a promising agent for treatment of oral candidiasis.

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