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Comparative Study
. 2010 Jan-Feb;17(1):19-26.
doi: 10.1007/s12350-009-9150-5. Epub 2009 Sep 24.

Incremental value of combining 64-slice computed tomography angiography with stress nuclear myocardial perfusion imaging to improve noninvasive detection of coronary artery disease

Akira Sato  1 , Toshihiro Nozato, Hiroyuki Hikita, Shinsuke Miyazaki, Yoshihide Takahashi, Taishi Kuwahara, Atsushi Takahashi, Michiaki Hiroe, Kazutaka Aonuma
Affiliations
Comparative Study

Incremental value of combining 64-slice computed tomography angiography with stress nuclear myocardial perfusion imaging to improve noninvasive detection of coronary artery disease

Akira Sato et al. J Nucl Cardiol. 2010 Jan-Feb.

Abstract

Background: To compare the accuracy of combined 64-slice computed tomography angiography (CTA) and stress nuclear myocardial perfusion imaging (MPI) in the noninvasive detection of coronary artery disease (CAD) with that of 64-slice CTA alone.

Methods and results: One hundred thirty symptomatic patients with suspected CAD underwent both 64-slice CTA and stress thallium-201 MPI before invasive coronary angiography (ICA). Coronary lesions with >or=50% luminal narrowing were considered as significant stenoses on CTA and ICA. Of 390 arteries in 130 patients, 54 (14%) were nonevaluable by CTA due to severe calcifications, motion artifacts, and/or poor opacification. All nonevaluable arteries were considered positive. The sensitivity, specificity, PPV and NPV were 95%, 80%, 69%, and 97%, respectively, for CTA alone and 94%, 92%, 85%, and 97%, respectively, for CTA with stress nuclear MPI for all nonevaluable arteries on CTA. Per-patient analysis showed significant increase in specificity and PPV. The majority (75%, 9/12) of nonevaluable severely calcified vessels in the left anterior descending artery were positive on stress nuclear MPI, whereas the majority (89%, 8/9) of nonevaluable vessels with motion artifacts in the right coronary artery were negative.

Conclusions: Combined CTA and stress nuclear MPI provide improved diagnostic accuracy for the noninvasive detection of CAD.

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Comment in

  • Multimodality cardiac imaging.
    Gaemperli O, Kaufmann PA. Gaemperli O, et al. J Nucl Cardiol. 2010 Jan-Feb;17(1):4-7. doi: 10.1007/s12350-009-9161-2. J Nucl Cardiol. 2010. PMID: 19876695 No abstract available.

References

    1. Eur Heart J. 2005 Aug;26(15):1482-7 - PubMed
    1. J Nucl Cardiol. 2000 Sep-Oct;7(5):432-8 - PubMed
    1. J Am Coll Cardiol. 2007 Mar 13;49(10):1059-67 - PubMed
    1. N Engl J Med. 2008 Nov 27;359(22):2324-36 - PubMed
    1. Circulation. 1998 Feb 17;97(6):535-43 - PubMed

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