Case Reports
doi: 10.1007/BF00703325.
Dense core vesicles around the Lewy body in incidental Parkinson's disease: an electron microscopic study
- PMID: 197775
- DOI: 10.1007/BF00703325
Item in Clipboard
Case Reports
Dense core vesicles around the Lewy body in incidental Parkinson's disease: an electron microscopic study
Acta Neuropathol.
.
Abstract
In a case of Lewy body disease incidentally found at autopsy, numerous dense core vesicles 80--200 nm in diameter, were seen in the neuronal perikarya of the locus caeruleus. They were particularly numerous in the vicinity of the Lewy bodies. The change seems to occur at the early stage of Lewy body production and may represent an additional morphologic clue to abnormal catecholamine metabolism in Parkinson's disease.
Similar articles
-
Synaptophysin and chromogranin A immunoreactivities of Lewy bodies in Parkinson's disease brains.Brain Res. 1994 Jan 21;634(2):339-44. doi: 10.1016/0006-8993(94)91940-2. Brain Res. 1994. PMID: 8131084
-
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):745-52. doi: 10.1136/jnnp.51.6.745. J Neurol Neurosurg Psychiatry. 1988. PMID: 2841426 Free PMC article. Review.
-
Spinal cord lesions in sporadic Parkinson's disease.Acta Neuropathol. 2012 Nov;124(5):643-64. doi: 10.1007/s00401-012-1028-y. Epub 2012 Aug 29. Acta Neuropathol. 2012. PMID: 22926675
-
An early cytoplasmic change before Lewy body maturation: an ultrastructural study of the substantia nigra from an autopsy case of juvenile parkinsonism.Acta Neuropathol. 1993;85(4):445-8. doi: 10.1007/BF00334457. Acta Neuropathol. 1993. PMID: 8480516
-
[An autopsy case of idiopathic parkinsonism with numerous Lewy bodies in the cerebral cortex--diffuse Lewy body disease].No To Shinkei. 1991 Feb;43(2):175-81. No To Shinkei. 1991. PMID: 1651748 Review. Japanese.
Cited by
-
Reverse engineering Lewy bodies: how far have we come and how far can we go?Nat Rev Neurosci. 2021 Feb;22(2):111-131. doi: 10.1038/s41583-020-00416-6. Epub 2021 Jan 11. Nat Rev Neurosci. 2021. PMID: 33432241 Review.
-
Defining a Lewy Body: Running Up the Hill of Shifting Definitions and Evolving Concepts.J Parkinsons Dis. 2024;14(1):17-33. doi: 10.3233/JPD-230183. J Parkinsons Dis. 2024. PMID: 38189713 Free PMC article. Review.
-
Female Sex and Brain-Selective Estrogen Benefit α-Synuclein Tetramerization and the PD-like Motor Syndrome in 3K Transgenic Mice.J Neurosci. 2019 Sep 18;39(38):7628-7640. doi: 10.1523/JNEUROSCI.0313-19.2019. Epub 2019 Aug 12. J Neurosci. 2019. PMID: 31405930 Free PMC article.
-
Biochemical and biophysical characterization of pathological aggregation of amyloid proteins.Biophys Rep. 2022 Feb 28;8(1):42-54. doi: 10.52601/bpr.2022.210032. Biophys Rep. 2022. PMID: 37287686 Free PMC article.
-
Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies.F1000Res. 2017 Aug 30;6:1604. doi: 10.12688/f1000research.11725.1. eCollection 2017. F1000Res. 2017. PMID: 28928962 Free PMC article. Review.