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. 2010 Feb;31(2):300-10.
doi: 10.1002/hbm.20865.

Source-based morphometry of gray matter volume in men with first-episode schizophrenia

Tomás Kaspárek  1 , Radek Marecek, Daniel Schwarz, Radovan Prikryl, Jirí Vanícek, Michal Mikl, Eva Cesková
Affiliations

Source-based morphometry of gray matter volume in men with first-episode schizophrenia

Tomás Kaspárek et al. Hum Brain Mapp. 2010 Feb.

Abstract

Objectives: There is a lot of variability between the results of studies reporting the pattern of gray matter volume changes in schizophrenia. Methodological issues may play an important role in this heterogeneity. The aim of the present study was to replicate the better performance of multivariate "source-based morphometry" (SBM) over the mass-univariate approach.

Experimental design: Voxel-based morphometry of Jacobian-modulated gray matter volume images, using voxel and cluster level inference, and SBM were performed in a group of first-episode schizophrenia patients (N = 49) and healthy controls (N = 127).

Results: Using SBM we were able to find a significant reduction of gray matter volume in fronto-temporo-cerebellar areas whereas no significant results were obtained using voxel-based morphometry.

Conclusion: Multivariate analysis of gray matter volume seems to be a suitable method for characterization of the pattern of changes at the beginning of the illness in schizophrenia subjects.

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Figures

Figure 1
Figure 1
Gray matter volume reduction in first‐episode schizophrenia—SBM results. Overlay of the three significantly different components, where first‐episode schizophrenia subjects had smaller gray matter volume. All the spatial components were thresholded at Z = 3. Left is on the left side of the image, anterior is toward the top of the image.
See this image and copyright information in PMC

References

    1. Andreasen NC, Paradiso S, O'Leary DS ( 1998): “Cognitive dysmetria” as an integrative theory of schizophrenia: A dysfunction in cortical‐subcortical‐cerebellar circuitry? Schizophr Bull 24: 203–218. - PubMed
    1. Andreasen NC, Pierson R ( 2008): The role of the cerebellum in schizophrenia. Biol Psychiatry 64: 81–88. - PMC - PubMed
    1. Ashburner J, Friston KJ ( 2000): Voxel‐based morphometry—The methods. Neuroimage 11 ( Part 1): 805–821. - PubMed
    1. Ashton L, Barnes A, Livingston M, Wyper D ( 2000): Cingulate abnormalities associated with PANSS negative scores in first episode schizophrenia. Behav Neurol 12 ( 1/2): 93–101. - PubMed
    1. Baiano M, David A, Versace A, Churchill R, Balestrieri M, Brambilla P ( 2007) Anterior cingulate volumes in schizophrenia: A systematic review and a meta‐analysis of MRI studies. Schizophr Res 93 ( 1–3): 1–12. - PubMed

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