Comment
doi: 10.1016/j.neuron.2009.09.017.
How DISC1 regulates postnatal brain development: girdin gets in on the AKT
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- PMID: 19778497
- DOI: 10.1016/j.neuron.2009.09.017
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How DISC1 regulates postnatal brain development: girdin gets in on the AKT
Neuron.
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Free article
Abstract
In this issue of Neuron, Kim et al. and Enomoto et al. show that DISC1 plays a key role in regulating postnatal brain development though interaction with Girdin. Girdin in turn regulates AKT signaling. Thus, another facet of the role of DISC1 is established, shedding more light on fundamental brain processes and the developmental basis of major psychiatric disorders.
Comment on
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DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212.Neuron. 2009 Sep 24;63(6):761-73. doi: 10.1016/j.neuron.2009.08.008. Neuron. 2009. PMID: 19778506 Free PMC article.
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Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.Neuron. 2009 Sep 24;63(6):774-87. doi: 10.1016/j.neuron.2009.08.015. Neuron. 2009. PMID: 19778507
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