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. 2009 Sep;29(9):1851-2.

[Antineoplastic effect of koumine in mice bearing H22 solid tumor]

[Article in Chinese]
Jing Cai  1 , Lin-sheng Lei, De-biao Chi
Affiliations
  • PMID: 19778809

[Antineoplastic effect of koumine in mice bearing H22 solid tumor]

[Article in Chinese]
Jing Cai et al. Nan Fang Yi Ke Da Xue Xue Bao. 2009 Sep.

Abstract

Objective: To investigate the antitumor effects of koumine in mice bearing H22 solid tumor and its effect on the immune system of the mice.

Methods: The changes in spleen and tumor weights and blood cell count were observed after koumine treatment in BALB/c athymic mice bearing H22 solid tumor, using normal saline solution and 5-Fu as the controls.

Results: Koumine significantly inhibited the tumor growth in a dose-dependent manner. The spleen index and blood cell counts in koumine group showed no significant differences from those in the saline control group, but higher than those in 5-Fu group.

Conclusion: Koumine can significantly inhibit the growth of H22 solid tumor without obvious inhibitory effect on the immune system in mice.

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