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. 2009 Oct;72(10):1884-7.
doi: 10.1021/np900250k.

Cytotoxic diterpenoids from Croton argyrophylloides

Hélcio S Santos  1 , Francisco W A Barros, Maria Rose Jane R Albuquerque, Paulo N Bandeira, Claúdia Pessoa, Raimundo Braz-Filho, Francisco J Q Monte, Jose Henrique Leal-Cardoso, Telma L G Lemos
Affiliations

Cytotoxic diterpenoids from Croton argyrophylloides

Hélcio S Santos et al. J Nat Prod. 2009 Oct.

Abstract

Two new diterpenes, 1 and 2, together with the known ent-15-oxo-kaur-16-en-18-oic acid (3), were isolated from the bark of Croton argyrophylloides. The structural characterization of 1 and 2 was determined on the basis of spectroscopic data interpretation. The cytotoxicity of each compound was evaluated against HL-60 (leukemia), MDAMB-435 (melanoma), SF-295 (glioblastoma), and HCT-8 (colon carcinoma) human tumor cell lines and against human peripheral blood mononuclear cells. The hemolytic potential in mouse erythrocytes was also tested for 1-3.

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