Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli
- PMID: 19781640
- DOI: 10.1016/j.resmic.2009.08.018
Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli
Abstract
General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins.
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