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Review
. 2009 Nov;160(9):629-36.
doi: 10.1016/j.resmic.2009.08.018. Epub 2009 Sep 22.

Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli

Ronny Schmidt  1 , Bernd Bukau, Axel Mogk
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Free article
Review

Principles of general and regulatory proteolysis by AAA+ proteases in Escherichia coli

Ronny Schmidt et al. Res Microbiol. 2009 Nov.
Free article

Abstract

General and regulated proteolysis in bacteria is crucial for cellular homeostasis and relies on high substrate specificity of the executing AAA+ proteases. Here we summarize the various strategies that tightly control substrate degradation from both sides: the generation of accessible degrons and their specific recognition by AAA+ proteases and cognate adaptor proteins.

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