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Comment
. 2009 Sep 24;35(6):735-6.
doi: 10.1016/j.molcel.2009.09.012.

Destruction of RhoA CULtivates actin

Shuangding Wu  1 , Dieter A Wolf
Affiliations
Comment

Destruction of RhoA CULtivates actin

Shuangding Wu et al. Mol Cell. .

Abstract

Cullin 3, the core subunit of the CRL3 ubiquitin ligase family, is essential for development, but its substrates remain poorly defined. Here, Chen et al. (2009) report that CRL3(BACURD) targets the RhoA GTPase for degradation, thereby maintaining actin cytoskeleton integrity.

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Figures

Figure 1
Figure 1. Model of CRL3BACURD-mediated destruction of RhoA
Active RhoA·GTP is converted to RhoA·GDP by GAP activity, which may respond to extracellular cues. RhoA·GDP, potentially after additional modification triggered by exogenous stimuli, is then recognized by a dimeric CRL3 complex containing hBACURDs1 and 2 as substrate receptors. Polyubiquitylation leads to proteasomal degradation of RhoA thus affecting actin dynamics, cell migration, and potentially metastasis.
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References

    1. Chen Y, Yang Z, Meng M, Zhao Y, Dong N, Yan H, Liu L, Ding MH, Peng HB, Shao F. Mol Cell. 2009 this issue. - PubMed
    1. Geyer R, Wee S, Anderson S, Yates JRr, Wolf DA. Mol Cell. 2003;12:783–790. - PubMed
    1. Jaffe AB, Hall A. Annual Review of Cell and Developmental Biology. 2005;21:247–269. - PubMed
    1. Kobayashi M, Yamamoto M. Antioxidants & Redox Signaling. 2005;7:385–394. - PubMed
    1. Loignon M, Miao W, Hu L, Bier A, Bismar TA, Scrivens JP, Mann K, Basik M, Bouchard A, Fiset PO, et al. Mol Cancer Ther. 2009;8:2432–2440. - PubMed

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