Comment
doi: 10.1016/j.molcel.2009.09.003.
The chicken or the egg: microRNA-mediated regulation of mRNA translation or mRNA stability
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- PMID: 19782024
- DOI: 10.1016/j.molcel.2009.09.003
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Comment
The chicken or the egg: microRNA-mediated regulation of mRNA translation or mRNA stability
Mol Cell.
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Free article
Abstract
In this issue of Molecular Cell, Fabian et al. (2009) demonstrate that in cell-free extracts from mouse Krebs-2 ascites, microRNA-mediated translational repression precedes target mRNA deadenylation, and identify GW182, PABP, and deadenylase subunits CAF1 and CCR4 as factors required for deadenylation.
Comment on
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Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.Mol Cell. 2009 Sep 24;35(6):868-80. doi: 10.1016/j.molcel.2009.08.004. Epub 2009 Aug 27. Mol Cell. 2009. PMID: 19716330 Free PMC article.
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