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Comment
. 2009 Sep 24;35(6):739-40.
doi: 10.1016/j.molcel.2009.09.003.

The chicken or the egg: microRNA-mediated regulation of mRNA translation or mRNA stability

Arina D Omer  1 , Maja M Janas, Carl D Novina
Affiliations
Free article
Comment

The chicken or the egg: microRNA-mediated regulation of mRNA translation or mRNA stability

Arina D Omer et al. Mol Cell. .
Free article

Abstract

In this issue of Molecular Cell, Fabian et al. (2009) demonstrate that in cell-free extracts from mouse Krebs-2 ascites, microRNA-mediated translational repression precedes target mRNA deadenylation, and identify GW182, PABP, and deadenylase subunits CAF1 and CCR4 as factors required for deadenylation.

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  • Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.
    Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR 3rd, Hannon GJ, Filipowicz W, Duchaine TF, Sonenberg N. Fabian MR, et al. Mol Cell. 2009 Sep 24;35(6):868-80. doi: 10.1016/j.molcel.2009.08.004. Epub 2009 Aug 27. Mol Cell. 2009. PMID: 19716330 Free PMC article.

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