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Review
. 2010 Apr 1;28(16):2806-9.
doi: 10.1016/j.vaccine.2009.09.047. Epub 2009 Sep 25.

Constructing target product profiles (TPPs) to help vaccines overcome post-approval obstacles

Bruce Y Lee  1 , Donald S Burke
Affiliations
Review

Constructing target product profiles (TPPs) to help vaccines overcome post-approval obstacles

Bruce Y Lee et al. Vaccine. .

Abstract

As history has demonstrated, post-approval obstacles can impede a vaccine's use and potentially lead to its withdrawal. Addressing these potential obstacles when changes in a vaccine's technology can still be easily made may improve a vaccine's chances of success. Augmented vaccine target product profiles (TPPs) can help vaccine scientists better understand and anticipate these obstacles and galvanize conversations among various vaccine stakeholders (e.g., scientists, marketers, business development managers, policy makers, public health officials, health care workers, third party payors, etc.) earlier in a vaccine's development.

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