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. 2009 Nov;28(11):1226-30.
doi: 10.1016/j.healun.2009.06.006. Epub 2009 Sep 26.

Fungal infections in pediatric lung transplant recipients: colonization and invasive disease

Michael Liu  1 , Sarah Worley, George B Mallory Jr, Sarah Arrigain, John Robertson, Marc G Schecter, Okan Elidemir, Lara A Danziger-Isakov
Affiliations

Fungal infections in pediatric lung transplant recipients: colonization and invasive disease

Michael Liu et al. J Heart Lung Transplant. 2009 Nov.

Abstract

Background: The purpose of this study was to evaluate the epidemiology and investigate the impact of colonization and pulmonary fungal infections (PFIs).

Methods: In this investigation we performed a retrospective analysis of 55 pediatric lung transplant recipients from 2002 to 2007 at a single institution. Associations between risk factors and time to post-transplant colonization, PFI, and other outcomes were assessed using Cox proportional hazard models.

Results: Although 29 patients had positive pre-transplant colonization, 33 (60%) were colonized post-transplant and 20% (11 subjects) developed proven or probable PFI. In a multivariate model, post-transplant fungal colonization was associated with older age (hazard ratio [HR] 2.9, 95% confidence interval [CI] 1.1 to 7.6), cytomegalovirus (CMV) prophylaxis (HR 5.6, 95% CI 1.3 to 24.6) and respiratory viral infection prior to fungal colonization (HR 2.9, 95% CI 1.0 to 8.3).

Conclusion: Neither fungal colonization nor PFI was associated with the development of chronic allograft rejection or death.

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Figures

Figure 1
Figure 1. Colonization and PFI
In Figure 1, patients are divided according to their colonization status (pre-transplant colonized, post-transplant de-novo colonization, or uncolonized). Further, patients with and without PFI after pediatric lung transplantation are identified for each category.
See this image and copyright information in PMC

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