Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2009 Oct;8(20):1902-3.
doi: 10.4161/cbt.8.20.9810. Epub 2009 Oct 14.

A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: promise or deja vu?

Andrew D Rhim  1
Affiliations
Comment

A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: promise or deja vu?

Andrew D Rhim. Cancer Biol Ther. 2009 Oct.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematized diagram of the pharmacologic inhibition of the convergence of the meK-erK and mtor pathways performed in Chang et al. Colored boxes indicate site of drug action. tSC2, tuberous sclerosis complex 2.
See this image and copyright information in PMC

Comment on

  • Cancer Biol Ther. 2009 Oct;8(20):1893-901

References

    1. American Cancer Society: Cancer Facts and Figures 2009. Atlanta, GA: American Cancer Society; 2009. [Last accessed 2009].
    1. Smit VT, Boot AJ, Smits AM, Fleuren GJ, Cornelisse CJ, Bos JL. KRAS codon 12 mutations occur very frequently in pancreatic adenocarcinoma. Nucleic Acids Res. 1988;16:7773–82. - PMC - PubMed
    1. Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988;53:549–54. - PubMed
    1. Chang Q, Chen E, Hedley DW. Effects of combined inhibition of MEK and mTOR on downstream signaling and tumor growth in pancreatic cancer xenograft models. Cancer Biol Ther. 2009:8. - PubMed
    1. Grewe M, Gansauge F, Schmid RM, Adler G, Seufferlein T. Regulation of cell growth and cyclin D1 expression by the constitutively active FRAP-p70s6K pathway in human pancreatic cancer cells. Cancer Res. 1999;59:3581–7. - PubMed

Publication types

MeSH terms