Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Aug 31;14(9):3268-74.
doi: 10.3390/molecules14093268.

Carnitine conjugate of nipecotic acid: a new example of dual prodrug

Carmela Napolitano  1 , Martina Scaglianti, Emanuela Scalambra, Stefano Manfredini, Luca Ferraro, Sarah Beggiato, Silvia Vertuani
Affiliations

Carnitine conjugate of nipecotic acid: a new example of dual prodrug

Carmela Napolitano et al. Molecules. .

Abstract

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.

PubMed Disclaimer

Figures

Scheme 1
Scheme 1
Conjugation of L-C to nipecotic acid.
Figure 1
Figure 1
Dose-response effect of conjugate 4 (0.75 mmol/kg ip) on pentylenetetrazole (PTZ)-induced convulsions in mice. Each point represents the mean ± SEM of 6-7 animals.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Hansch C., Bjorkroth J.P., Leo A. Hydrophobicity and central nervous system agents: On the principle of minimal hydrophobicity in drug design. J. Pharm. Sci. 1987;76:663–687. - PubMed
    1. Testa B., Carrupt P.A., Gaillard P., Billois F., Weber P. Lipophilicity in molecular modelling. Pharm. Res. 1996;13:335–343. doi: 10.1023/A:1016024005429. - DOI - PubMed
    1. Tamai I., Tsuji A. Transporter mediated permeation of drugs across the blood-brain barrier. J. Pharm. Sci. 2000;89:1371–1388. doi: 10.1002/1520-6017(200011)89:11<1371::AID-JPS1>3.0.CO;2-D. - DOI - PubMed
    1. Manfredini S., Pavan B., Vertuani S., Scaglianti M., Compagnone D., Biondi C., Scatturin A., Tanganelli S., Ferraro L., Prasad P., Dalpiaz A. Design, synthesis and activity of ascorbic acid prodrugs of nipecotic, kynurenic and diclophenamic acids, liable to increase neurotropic activiy. J. Med. Chem. 2002;45:559–562. doi: 10.1021/jm015556r. - DOI - PubMed
    1. Bahl J.J., Bressler R. The pharmacology of carnitine. Ann. Rev. Pharmacol. Toxicol. 1987;27:257–277. doi: 10.1146/annurev.pa.27.040187.001353. - DOI - PubMed

Publication types