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. 2009 Aug 31;14(9):3268-74.
doi: 10.3390/molecules14093268.

Carnitine conjugate of nipecotic acid: a new example of dual prodrug

Carmela Napolitano  1 , Martina Scaglianti, Emanuela Scalambra, Stefano Manfredini, Luca Ferraro, Sarah Beggiato, Silvia Vertuani
Affiliations

Carnitine conjugate of nipecotic acid: a new example of dual prodrug

Carmela Napolitano et al. Molecules. .

Abstract

As a novel example of improved entry of poorly delivered drugs into the brain by means of nutrient conjugates, L-carnitine was conjugated to nipecotic acid and the capacity to antagonize PTZ-induced convulsions of this novel entity was evaluated.

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Figures

Scheme 1
Scheme 1
Conjugation of L-C to nipecotic acid.
Figure 1
Figure 1
Dose-response effect of conjugate 4 (0.75 mmol/kg ip) on pentylenetetrazole (PTZ)-induced convulsions in mice. Each point represents the mean ± SEM of 6-7 animals.
See this image and copyright information in PMC

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