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. 2009;48(44):8328-30.
doi: 10.1002/anie.200903888.

Tunable, temperature-responsive polynorbornenes with side chains based on an elastin peptide sequence

Rosemary M Conrad  1 , Robert H Grubbs
Affiliations

Tunable, temperature-responsive polynorbornenes with side chains based on an elastin peptide sequence

Rosemary M Conrad et al. Angew Chem Int Ed Engl. 2009.
No abstract available

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Figures

Figure 1
Figure 1
Log plot of the random copolymerization of monomers 1 (triangles) and 2 (squares) with [1]0 = [2]0 = 0.01 M and [1 + 2]0/[3]0 = 40 in 4:1 CD2Cl2/CD3OD. Linear least-squares fitting gave slope and R2 values, respectively, of the following: monomer 1, (0.45, 0.996) and monomer 2, (0.42, 0.997).
Figure 2
Figure 2
Turbidity measurements for polymers of a) varying elastin content: solid line, 60%; dotted line, 50 %; short dash, 40% elastin; dash-dot, 33%; and b) varying molecular weight (as determined by GPC): solid line, 64 kDa; dotted line, 47 kDa; short dash, 40 kDa; dash-dot, 29 kDa; long dash, 15 kDa. Measurements were taken at pH 2, 0.5 mg/mL and heating at a rate of 0.5 °C/min. Absorbance values have been normalized to 1.
Figure 2
Figure 2
Turbidity measurements for polymers of a) varying elastin content: solid line, 60%; dotted line, 50 %; short dash, 40% elastin; dash-dot, 33%; and b) varying molecular weight (as determined by GPC): solid line, 64 kDa; dotted line, 47 kDa; short dash, 40 kDa; dash-dot, 29 kDa; long dash, 15 kDa. Measurements were taken at pH 2, 0.5 mg/mL and heating at a rate of 0.5 °C/min. Absorbance values have been normalized to 1.
Figure 3
Figure 3
Concentration dependence of LCST of polymer 9 at pH 2.
Scheme 1
Scheme 1
ROMP of elastin-like monomers with PEG5 comonomers.
See this image and copyright information in PMC

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