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. 2009 Oct;51(10):1158-66.
doi: 10.1097/JOM.0b013e3181b967aa.

Association between fine particulate matter and oxidative DNA damage may be modified in individuals with hypertension

Jee Young Kim  1 , Lacey A Prouty, Shona C Fang, Ema G Rodrigues, Shannon R Magari, Geoffrey A Modest, David C Christiani
Affiliations

Association between fine particulate matter and oxidative DNA damage may be modified in individuals with hypertension

Jee Young Kim et al. J Occup Environ Med. 2009 Oct.

Abstract

Objective: To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals.

Methods: Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG.

Results: Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day.

Conclusions: The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.

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Figures

Figure 1
Figure 1
Crude scatterplots of 12-hour-average PM2.5 concentrations (on natural log scale) and urinary 8-OHdG concentrations in individuals with hypertension (A, including all data points; B, excluding two outlying data points) and without hypertension (C). (A) Individuals with hypertension (n = 12; 30 data points) (B) Individuals with hypertension, excluding two outlying data points (n = 12; 28 data points) (C) Individuals without hypertension (n = 9; 25 data points)
Figure 1
Figure 1
Crude scatterplots of 12-hour-average PM2.5 concentrations (on natural log scale) and urinary 8-OHdG concentrations in individuals with hypertension (A, including all data points; B, excluding two outlying data points) and without hypertension (C). (A) Individuals with hypertension (n = 12; 30 data points) (B) Individuals with hypertension, excluding two outlying data points (n = 12; 28 data points) (C) Individuals without hypertension (n = 9; 25 data points)
Figure 1
Figure 1
Crude scatterplots of 12-hour-average PM2.5 concentrations (on natural log scale) and urinary 8-OHdG concentrations in individuals with hypertension (A, including all data points; B, excluding two outlying data points) and without hypertension (C). (A) Individuals with hypertension (n = 12; 30 data points) (B) Individuals with hypertension, excluding two outlying data points (n = 12; 28 data points) (C) Individuals without hypertension (n = 9; 25 data points)
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