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. 2009 Sep;6(9):e1000111.
doi: 10.1371/journal.pmed.1000111. Epub 2009 Sep 29.

Considering usual medical care in clinical trial design

Liza Dawson  1 , Deborah A Zarin, Ezekiel J Emanuel, Lawrence M Friedman, Bimal Chaudhari, Steven N Goodman
Affiliations

Considering usual medical care in clinical trial design

Liza Dawson et al. PLoS Med. 2009 Sep.

Abstract

Liza Dawson and colleagues discuss the scientific and ethical issues associated with choosing clinical trial designs when there is no consensus on what constitutes usual care.

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Conflict of interest statement

DZ is employed by the National Institutes of Health as a senior scientist, and the Director, ClinicalTrials.gov. She has no other relevant interests. LMF is now retired but was an employee of the NIH institute (the National Heart, Lung, and Blood Institute) that funded the ARDS Network, and was a senior-level NHLBI employee at the time of the controversy regarding the ARDSNet study that stimulated the conference discussed in the paper.

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