Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2008 Apr 10:2:57-73.

The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy

Xinjie Lu  1 , Dong Lu, Mike Scully, Vijay Kakkar
Affiliations

The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy

Xinjie Lu et al. Perspect Medicin Chem. .

Abstract

Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression. This review considers the potential role of integrins in cancer and also addresses why integrins are present attractive targets for drug design. It discusses of the several properties of the integrin-based chemotherapeutic agents currently under consideration clinically and provides an insight into cancer drug development using integrin as a target.

Keywords: cancer; disintegrin; integrin; ligand.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Structure of the extracellular segment of αVβ3 derived with permission from Xiong et al. 2002. (A) Bent conformation of αVβ3 as it was present in the crystal. (B) Extension of the structure to reveal its domains.
See this image and copyright information in PMC

References

    1. Ahmed N, Riley C, Rice GE, et al. Alpha(v)beta(6) integrin-A marker for the malignant potential of epithelial ovarian cancer. J. Histochem. Cytochem. 2002;50:1371–80. - PubMed
    1. Ahmed N, Riley C, Rice G, et al. Role of integrin receptors for fibronectin, collagen and laminin in the regulation of ovarian carcinoma functions in response to a matrix microenvironment. Clin. Exp. Metastasis. 2005;22:391–402. - PubMed
    1. Agrez M, Gu X, Turton J, et al. The alpha v beta 6 integrin induces gelatinase B. secretion in colon cancer cells. Int. J. Cancer. 1999;81:90–7. - PubMed
    1. Alghisi GC, Ruegg C. Vascular integrins in tumor angiogenesis: mediators and therapeutic targets. Endothelium. 2006;13:113–35. - PubMed
    1. Anderson JA, Grabowska AM, Watson SA. PTHrP increases transcriptional activity of the integrin subunit alpha(5) Br J Cancer 2007 - PMC - PubMed

LinkOut - more resources