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. 2010 Feb 1;78(2):492-5.
doi: 10.1002/prot.22600.

Crystal structure of the DNA gyrase GyrA N-terminal domain from Mycobacterium tuberculosis

Elsa M Tretter  1 , Allyn J Schoeffler, Shellie R Weisfield, James M Berger
Affiliations

Crystal structure of the DNA gyrase GyrA N-terminal domain from Mycobacterium tuberculosis

Elsa M Tretter et al. Proteins. .
No abstract available

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Figures

Figure 1
Figure 1
MtGyr59 structure. A) Representative electron density from a refined 2Fo-Fc map contoured at 2σ. B) Cartoon representation (Pymol) of the MtGyr59 dimer. The active site Tyrosine (Tyr129) is highlighted pink. C) Structural alignments of the MtGyr59 (yellow) and EcGyrA59 (fuchsia) helix α4 region. Gly88 and Asp82 are shown as space filling spheres to highlight the clashes that would occur if MtGyr59 region adopted the same structure as seen in EcGyrA59. Asp89 of MtGyrA59 is also shown, together with moxifloxacin superposed from the S. pneumoniae topo IV co-crystal structure, to highlight how the MtGyr59 loop would clash with bound drug. D) Overlay of the DNA bending loop region between MtGyr59 (yellow) and EcGyrA59 (fuchsia).
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References

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