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. 2009 Oct;201(4):402.e1-5.
doi: 10.1016/j.ajog.2009.06.065.

Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes

S Katherine Laughon  1 , Janet Catov, Traci Provins, James M Roberts, Robin E Gandley
Affiliations

Elevated first-trimester uric acid concentrations are associated with the development of gestational diabetes

S Katherine Laughon et al. Am J Obstet Gynecol. 2009 Oct.

Abstract

Objective: We sought to demonstrate that elevated first-trimester uric acid is associated with development of gestational diabetes mellitus (GDM).

Study design: Uric acid was measured in 1570 plasma samples collected at mean gestational age of 8.9 +/- 2.5 weeks. The primary outcome was GDM, diagnosed by 3-hour glucose tolerance test using Carpenter and Coustan criteria or by a 1-hour value of > or =200 mg/dL. Logistic regression was performed, adjusting for relevant covariates.

Results: Almost half (46.6%) of the women with GDM had first-trimester uric acid concentrations in the highest quartile (>3.57-8.30 mg/dL). Women with uric acid in the highest quartile had a 3.25-fold increased risk (95% confidence interval, 1.35-7.83) of developing GDM after adjustment for body mass index and age. This effect was concentration dependent as risk increased with increasing uric acid quartiles (P = .003).

Conclusion: First-trimester hyperuricemia is associated with an increased risk of developing GDM, independent of body mass index.

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Figures

Figure 1
Figure 1
Receiver operator curve adjusted for maternal age, prepregancy BMI (kg/m2) and gestational age of sample. First trimester uric acid concentration and risk of developing gestational diabetes mellitus
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