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. 2009 Oct;146(4):543-52; discussion 552-3.
doi: 10.1016/j.surg.2009.06.052.

The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: the untold story

Anton I Skaro  1 , Colleen L Jay, Talia B Baker, Edward Wang, Sarina Pasricha, Vadim Lyuksemburg, John A Martin, Joseph M Feinglass, Luke B Preczewski, Michael M Abecassis
Affiliations

The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death: the untold story

Anton I Skaro et al. Surgery. 2009 Oct.

Abstract

Background: Liver transplantation (LT) from donation after cardiac death (DCD) donors is increasingly being used to address organ shortages. Despite encouraging reports, standard survival metrics have overestimated the effectiveness of DCD livers. We examined the mode, kinetics, and predictors of organ failure and resource utilization to more fully characterize outcomes after DCD LT.

Methods: We reviewed the outcomes for 32 DCD and 237 donation after brain death (DBD) LT recipients at our institution.

Results: Recipients of DCD livers had a 2.1 times greater risk of graft failure, a 2.5 times greater risk of relisting, and a 3.2 times greater risk of retransplantation compared with DBD recipients. DCD recipients had a 31.6% higher incidence of biliary complications and a 35.8% higher incidence of ischemic cholangiopathy. Ischemic cholangiography was primarily implicated in the higher risk of graft failure observed after DCD LT. DCD recipients with ischemic cholangiography experienced more frequent rehospitalizations, longer hospital stays, and required more invasive biliary procedures.

Conclusion: Related to higher complication rates, DCD recipients necessitated greater resource utilization. This more granular data should be considered in the decision to promote DCD LT. Modification of liver allocation policy is necessary to address those disadvantaged by a failing DCD graft.

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Figures

Figure 1A-1D
Figure 1A-1D
Kaplan-Meier analysis: patient survival, graft survival, re-list and re-transplantation for DCD ans DBD liver transplanation.
Figure 2
Figure 2
illustrates a representative example of an endoscopic retrograde cholangio-pancreatogram performed on a patient with persistend fevers and elevated liver function teste 6 months post transplant. Figure 2A depicts the cholangiogram showing diffuse ischemic cholangiogram. Figure 2B shows the endoscopic of an occlusive bile duct cast which is then shown ex vivo in figure 2C.
See this image and copyright information in PMC

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