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. 2009 Oct;13(10):1309-12.

Prevalence of extensively drug-resistant tuberculosis in Vladimir and Orel regions, Russia

V V Punga  1 , W M Jakubowiak, I D Danilova, T R Somova, G V Volchenkov, B Y Kazionnyy, E S Nemtsova, E V Kiryanova, E V Kourbatova
Affiliations
  • PMID: 19793439

Prevalence of extensively drug-resistant tuberculosis in Vladimir and Orel regions, Russia

V V Punga et al. Int J Tuberc Lung Dis. 2009 Oct.

Abstract

Setting: Joint World Health Organization (WHO) projects in Vladimir and Orel regions, Russia.

Objective: To study the prevalence of extensively drug-resistant (XDR) tuberculosis (TB).

Methods: Drug susceptibility testing of second-line drugs (ofloxacin, kanamycin, capreomycin, ethionamide, cycloserine and para-aminosalicylic acid) was performed on isolates from multidrug-resistant TB cases from 1 January to 31 December 2006.

Results: In Orel, 16 (21.3%) of 75 tested isolates were XDR-TB; in Vladimir, 9 (4.9%) of 182 isolates were XDR-TB. Bilateral lung involvement was significantly associated with XDR-TB (prevalence ratio = 2.61, 95%CI 1.01-6.72).

Conclusion: XDR-TB has emerged in Russia. It is crucial to prevent, diagnose and treat TB and MDR-TB more effectively.

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