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Review
. 2009 Oct;18(4):637-45.
doi: 10.1016/j.soc.2009.07.003.

Familial colorectal cancer type X: the other half of hereditary nonpolyposis colon cancer syndrome

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Review

Familial colorectal cancer type X: the other half of hereditary nonpolyposis colon cancer syndrome

Noralane M Lindor. Surg Oncol Clin N Am. 2009 Oct.

Abstract

Establishing the Amsterdam criteria, based on pedigrees, was essential for defining hereditary nonpolyposis colorectal cancer (HNPCC) syndrome in such a way that the underlying genetic cause could be identified. It is now known that about half of families that fulfill the original Amsterdam criteria have a hereditary DNA mismatch repair (MMR) gene mutation. These families may be said to have Lynch syndrome. The other half of families with HNPCC has no evidence of DNA MMR deficiency, and studies show that these families are different from families with Lynch syndrome. Familial colorectal cancer type X is the name used to refer to the "other half of HNPCC".

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References

    1. Warthin A. Heredity with reference to carcinoma as shown by the study of the cases examined in the pathological laboratory of the University of Michigan 1895–1913. Arch Intern Med. 1913;12:546–55. - PubMed
    1. Merg A, Lynch H, Lynch J, et al. Hereditary colorectal cancer-part II. Curr Probl Surg. 2005;42(5):267–333. - PubMed
    1. Lynch H, Shaw M, Magnuseo C, et al. Hereditary factors in cancer: study of two large Midwestern Kindreds. Arch Intern Med. 1966;117:206–12. - PubMed
    1. Vasen H, Mecklin J, Khan P, et al. The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC) Dis Colon Rectum. 1991;334(5):424–25. - PubMed
    1. Burke W, Petersen G, Lynch P, et al. Recommendations for follow-up care of individuals with an inherited predisposition to cancer. I. Hereditary nonpolyposis colon cancer. Cancer Genetics Studies Consortium. JAMA. 1997;277(11):915–19. - PubMed

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