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Review
. 2009 Oct;58(10):2175-84.
doi: 10.2337/db09-0476.

Current advances and travails in islet transplantation

David M Harlan  1 , Norma Sue Kenyon, Olle Korsgren, Bart O Roep; Immunology of Diabetes Society
Affiliations
Review

Current advances and travails in islet transplantation

David M Harlan et al. Diabetes. 2009 Oct.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Potential alternative islet implantation sites. Efforts directed to promote improved islet graft function and survival have led to studies testing alternative implantation sites, mostly in preclinical animal models, although the intramuscular route has shown some promise in the clinic (72). Recent pig model studies (73) have suggested promise for endoscopic transplant of the islets into the gastric submucosal space.
FIG. 2.
FIG. 2.
Recognizing the tremendous disparity between the islet number that can be isolated from cadaveric donors and the potential recipient population, many investigators are working to develop a renewable and cost-efficient source of islets or islet-like clusters. Each strategy has potential advantages but also unique problems to overcome.
FIG. 3.
FIG. 3.
Factors limiting islet graft function and survival. Present understanding is that transplanted islets (or islet-like clusters) face myriad overlapping forces all conspiring to limit graft function and/or survival. Effective strategies to develop islet transplantation for widespread clinical application will likely require effective countermeasures for each identified problem.
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References

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