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Editorial
. 2009 Oct;94(10):1341-5.
doi: 10.3324/haematol.2009.012161.

Large granular lymphocyte disorders: new etiopathogenetic clues as a rationale for innovative therapeutic approaches

Renato Zambello, Gianpietro Semenzato
Editorial

Large granular lymphocyte disorders: new etiopathogenetic clues as a rationale for innovative therapeutic approaches

Renato Zambello et al. Haematologica. 2009 Oct.

Abstract

The pathogenesis of large granular lymphocytic disorders is now being unravelled. Knowledge of the various cells of origin and the (often viral) drivers of proliferation is emerging. Leukemic transformation involves acquisition of mechanisms to escape death and to continue to proliferate. In this perspective article, Drs. Zambello and Semenzato examine new etiopathogenetic clues as a rationale for innovative therapeutic approaches. See related article on page 1407.

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Figures

Figure 1.
Figure 1.
Different mechanisms accounting for cytopenias in patients with T-LGL leukemia or CLPD-NK. NK: natural killer;TNF: tumor necrosis factor; IFN: interferon.
See this image and copyright information in PMC

Comment on

References

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