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Comparative Study
. 2009 Oct;94(10):1460-4.
doi: 10.3324/haematol.2008.004721.

Prior history of non-melanoma skin cancer is associated with increased mortality in patients with chronic lymphocytic leukemia

Jorge R Toro  1 , Patrick W Blake, Magnus Björkholm, Sigurdur Y Kristinsson, Zhuoqiao Wang, Ola Landgren
Affiliations
Comparative Study

Prior history of non-melanoma skin cancer is associated with increased mortality in patients with chronic lymphocytic leukemia

Jorge R Toro et al. Haematologica. 2009 Oct.

Abstract

We investigated whether a previous diagnosis of non-melanoma skin cancer among chronic lymphocytic leukemia patients is a predictor of poor outcome. Using the Swedish Cancer Registry, we conducted a population-based study to evaluate the survival patterns among chronic lymphocytic leukemia patients with and without non-melanoma skin cancer. Cox proportional hazards regression models were used and Kaplan-Meier curves were constructed. Of a total of 12,041 chronic lymphocytic leukemia cases identified, 236 cases, including 111 squamous cell cancer, had a prior history of non-melanoma skin cancer. Chronic lymphocytic leukemia patients with a prior history of non-melanoma skin cancer had a 1.29-fold (95% CI 1.10-1.52; p=0.0024) increased risk of dying; and those with a history of squamous cell cancer had a further elevated 1.86-fold (95% CI 1.46-2.36; p<0.0001) risk of dying. Kaplan-Meier plots showed that patients with a history of non-melanoma skin cancer, particularly those with squamous cell cancer, had significantly poorer survival than chronic lymphocytic leukemia patients without non-melanoma skin cancer (p<0.0001; log-rank test). Non-melanoma skin cancer may be a novel clinical predictor of worse chronic lymphocytic leukemia outcome.

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Figures

Figure 1.
Figure 1.
Time between first diagnosis of non-melanoma skin cancers, including squamous cell cancer, and chronic lymphocytic leukemia diagnosis.
Figure 2.
Figure 2.
Kaplan-Meier plots showing 5-year cumulative survival after diagnosis of chronic lymphocytic leukemia among patients with and without non-melanoma skin cancer and squamous cell carcinoma, respectively.
See this image and copyright information in PMC

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