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Clinical Trial
. 2010 Jul;14(1):57-68.
doi: 10.1177/1087054709347435. Epub 2009 Sep 30.

Validation of the adult ADHD investigator symptom rating scale (AISRS)

Thomas J Spencer  1 , Lenard A Adler, Meihua Qiao, Keith E Saylor, Thomas E Brown, James A Holdnack, Kory J Schuh, Paula T Trzepacz, Douglas K Kelsey
Affiliations
Clinical Trial

Validation of the adult ADHD investigator symptom rating scale (AISRS)

Thomas J Spencer et al. J Atten Disord. 2010 Jul.

Abstract

Objective: Validation of the Adult ADHD Investigator Symptom Rating Scale (AISRS) that measures aspects of ADHD in adults.

Method: Psychometric properties of the AISRS total and AISRS subscales are analyzed and compared to the Conners' Adult Attention-Deficit/Hyperactivity Disorder Rating Scale-Investigator Rated: Screening Version (CAARS-Inv:SV) and the Clinical Global Impression-ADHD-Severity Scale using data from a placebo-controlled 6-month clinical trial of once-daily atomoxetine.

Results: The AISRS has high internal consistency, good convergent, and discriminant validities; modest divergent validity; and small ceiling and floor effects (<or=1%). It correlates highly with the CAARS-Inv:SV. Factor analysis confirms 2 AISRS subscales, hyperactivity-impulsive scale and inattention. The AISRS total and AISRS subscales perform stably. All scales demonstrate responsiveness to change with medication.

Conclusion: The AISRS and its subscales are robust, valid efficacy measures of ADHD symptoms in adult patients. Its anchored items and semistructured interview are advancements over existing scales.

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