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Comparative Study
. 1990 Jul-Aug;35(4):322-6.

[Monoclonal antibodies to the Karelian fever virus. The characteristics of their biological properties]

[Article in Russian]
L V Uryvaev, N A Parasiuk, K S Ionova, T G Mikheeva, A Iu Zlobin, T M Skvortsova, E E Mel'nikova, O P Glushchenko, D K L'vov
  • PMID: 1979458
Comparative Study

[Monoclonal antibodies to the Karelian fever virus. The characteristics of their biological properties]

[Article in Russian]
L V Uryvaev et al. Vopr Virusol. 1990 Jul-Aug.

Abstract

Biological properties of 6 variants of monoclonal antibodies (MAb) to Karelian fever virus, a member of the alpha-virus serocomplex Sindbis-WEE, produced by the available hybridomas. The productivity of hybridomas of the "Karel" series in tissue culture and in cultivation as ascitic fluid was evaluated. Among the antibodies analysed, all were specific to envelope proteins, of them 2 were against protein E2 and four against protein E1. Comparison of MCA biologic activity (neutralizing, antihemagglutinating activities, participation in immunofluorescence, EIA, and immune blotting) allows one to distinguish four different hybridomas among them producing specific antibodies differing in their properties.

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