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Review
. 2008 Oct-Dec;1(1):15-24.
doi: 10.4161/oxim.1.1.6843.

Antioxidant systems and oxidative stress in the testes

R John Aitken  1 , Shaun D Roman
Affiliations
Free PMC article
Review

Antioxidant systems and oxidative stress in the testes

R John Aitken et al. Oxid Med Cell Longev. 2008 Oct-Dec.
Free PMC article
No abstract available

Keywords: antioxidant enzymes; oxidative stress; reactive oxygen species; spermatogenesis; testes.

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Figures

Figure 1
Figure 1
Major pathways of reactive oxygen species generation and metabolism. Superoxide can be generated by specialized enzymes, such as the xanthine or NADPH oxidases, or as a by-product of cellular metabolism, particularly the mitochondrial electron transport chain. Superoxide dismutase then converts the superoxide to hydrogen peroxide which has to be rapidly removed from the system. This is generally achieved by catalase or peroxidases, such as the glutathione peroxidases which use reduced glutathione (GSH) as the electron donor.
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