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Randomized Controlled Trial
. 2009 Oct;24(5):879-82.
doi: 10.3346/jkms.2009.24.5.879. Epub 2009 Sep 24.

Antihistamine pretreatment to reduce incidence of withdrawal movement after rocuronium injection

Ho Jun Lee  1 , Sung Jin Han, Heezoo Kim, Il Ok Lee, Myoung Hoon Kong, Nan Suk Kim, Sang Ho Lim, Mi Kyoung Lee
Affiliations
Randomized Controlled Trial

Antihistamine pretreatment to reduce incidence of withdrawal movement after rocuronium injection

Ho Jun Lee et al. J Korean Med Sci. 2009 Oct.

Abstract

The purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery were randomly assigned to one of two groups. Patients in the control group (Group C) were premedicated with 2 mL normal saline, and those in the antihistamine group (Group A) were pre-medicated with 2 mL (45.5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected. Withdrawal movements were assessed using a four-grade scale. The administration of antihistamine reveals lower grade of withdrawal movement after rocuronium injection.

Keywords: Antihistamine; Pain; Rocuronium.

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Figures

Fig. 1
Fig. 1
Response to administration of rocuronium in patients pretreated with antihistamine versus saline depends on intravenous catheter site. Values represent numbers of patients or withdrawal grade.
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