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. 2009 Oct;24(5):904-9.
doi: 10.3346/jkms.2009.24.5.904. Epub 2009 Sep 23.

Unrelated hematopoietic stem cell transplantation for children with acute leukemia: experience at a single institution

Jae Hee Lee  1 , Hoi Soo Yoon, Joon Sup Song, Eun Seok Choi, Hyung Nam Moon, Jong Jin Seo, Ho Joon Im
Affiliations

Unrelated hematopoietic stem cell transplantation for children with acute leukemia: experience at a single institution

Jae Hee Lee et al. J Korean Med Sci. 2009 Oct.

Abstract

We evaluate the outcomes in children with acute leukemia who received allogeneic hematopoietic stem cell transplantation (HCT) using unrelated donor. Fifty-six children in complete remission (CR) received HCT from unrelated donors between 2000 and 2007. Thirty-five had acute myeloid leukemia, and 21 had acute lymphoid leukemia. Stem cell sources included bone marrow in 38, peripheral blood in 4, and cord blood (CB) in 14. Four patients died before engraftment and 52 engrafted. Twenty patients developed grade II-IV acute graft-versus-host disease (GVHD) and 8 developed extensive chronic GVHD. With median follow-up of 39.1 months, event free survival and overall survival were 60.4% and 67.5%, respectively, at 5 yr. Events included relapse in 10 and treatment-related mortality (TRM) in 10. The causes of TRM included sepsis in 4, GVHD in 4 (1 acute GVHD and 3 chronic GVHD), veno-occlusive disease in 1 and fulminant hepatitis in 1. Patients transplanted with CB had event free survival of 57.1%, comparable to 63.2% for those transplanted with other than CB. In conclusion, HCT with unrelated donors is effective treatment modality for children with acute leukemia. In children with acute leukemia candidate for HCT but lack suitable sibling donor, unrelated HCT may be a possible treatment option at the adequate time of their disease.

Keywords: Acute Leukemia; Allogeneic Hematopoietic Stem Cell Transplantation; Child; Unrelated Donor.

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Figures

Fig. 1
Fig. 1
Engraftment rate of neutrophils (A) and platelets (B) according to stem cell sources.
Fig. 2
Fig. 2
Probability of 5 yr event free survival (EFS) (A) and overall survial (OS) (B) according to disease.
See this image and copyright information in PMC

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