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Comparative Study
. 2009 Oct;24(5):941-4.
doi: 10.3346/jkms.2009.24.5.941. Epub 2009 Sep 23.

Increased transforming growth factor-beta1 in alcohol dependence

Yong-Ku Kim  1 , Boung Chul Lee, Byung Joo Ham, Byung-Hwan Yang, Sungwon Roh, Joonho Choi, Tae-Cheon Kang, Young-Gyu Chai, Ihn-Geun Choi
Affiliations
Comparative Study

Increased transforming growth factor-beta1 in alcohol dependence

Yong-Ku Kim et al. J Korean Med Sci. 2009 Oct.

Abstract

Ethanol and its metabolite acetaldehyde increase transforming growth factor beta1 (TGF-beta1) expression in animal studies. TGF-beta1 is related with the hepatic stellate cell (the key element of hepatic fibrogenesis) and the radial glia (the key element of neuronal migration). Blood samples were collected from 41 patients with alcohol dependence, TGF-beta1 levels measured by ELISA were compared with 41 normal subjects. Plasma TGF-beta1 levels in the patients with alcohol dependence (1,653.11+/-532.45 pg/mL) were significantly higher than those of healthy subjects (669.87+/-366.53 pg/mL) (P=0.000). Patients with or without liver pathology showed no difference in TGF-beta1 (P=0.36). Increased TGF-beta1 may mediate deleterious effect of alcohol such as hepatic fibrosis and suppressed neuronal developments in alcohol dependence patients.

Keywords: Alcohols; Transforming Growth Factor beta1.

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Figures

Fig. 1
Fig. 1
Plasma TGF-β1 level between alcohol dependence patients and normal controls.
Fig. 2
Fig. 2
Plasma TGF-β1 levels of alcohol dependence patients with or without liver pathology and normal controls. AD, alcohol dependence; LD, liver disese.
See this image and copyright information in PMC

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