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. 2009 Dec:30 Suppl 2:207-9.
doi: 10.1007/s00292-009-1223-3.

[BRCA1- and BRCA2- associated breast carcinomas]

[Article in German]
P Ahrens  1 , H H Kreipe
Affiliations

[BRCA1- and BRCA2- associated breast carcinomas]

[Article in German]
P Ahrens et al. Pathologe. 2009 Dec.

Abstract

Breast cancers with a genetic BRCA1-/BRCA2 background differ from each other and sporadic cases. A specific pathological surrogate marker, however, does not exist. In this study the results of a German reference centre are reported. BRCA1 associated cancers are predominantly high grade (G3), triple negative, highly proliferative (median Ki-67 55%) and only exceptionally accompanied by lobular intraepithelial neoplasia. Cancers with a BRCA2 germ line mutation are less frequent and resemble sporadic cases with a comparably higher proliferative activity and a lack of Her2 overexpression.

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