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Review
. 2009 Nov;29(6):714-21.
doi: 10.1007/s10875-009-9333-5.

Autoimmunity, infectious immunity, and atherosclerosis

Eiji Matsuura  1 , Kazuko Kobayashi, Yukana Matsunami, Lianhua Shen, Nanhu Quan, Marina Makarova, Sergey V Suchkov, Kiyoshi Ayada, Keiji Oguma, Luis R Lopez
Affiliations
Review

Autoimmunity, infectious immunity, and atherosclerosis

Eiji Matsuura et al. J Clin Immunol. 2009 Nov.

Abstract

Introduction: Vascular inflammation is common in certain systemic autoimmune diseases and contributes to the oxidation of low-density lipoprotein (oxLDL) and oxLDL/beta2-glycoprotein I (beta2GPI) complex formation. These complexes have been implicated as proatherogenic autoantigens that participate in the development of atherosclerotic disease.

Discussion: We have demonstrated that the in vitro macrophage uptake of oxLDL/beta2GPI complexes increases in the presence of IgG anti-beta2GPI antibodies and that IgG immune complexes containing oxLDL/beta2GPI upregulate the expression of both scavenger and Fcgamma receptors to activate beta2GPI specific T cells. Some persistent infections may cause immune responses that promote atherogenesis. Cellular immunity (Th1) against Helicobacter pylori (H. pylori) derived heat shock protein 60 (Hp-HSP60) cross-reacts with endogenous HSP60 to cause cardiovascular disease likely by molecular mimicry.

Conclusion: Infectious cellular response may be proatherogenic,while the humoral response (antibody production) maybe protective. We review the recent progress in our understanding of autoimmunity and infectious immunity that promote atherosclerosis.

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