Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems
- PMID: 19796372
- PMCID: PMC2787266
- DOI: 10.1186/ar2786
Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems
Abstract
In a previous issue of Arthritis Research and Therapy, Ursum and colleagues report the relative stabilities of anticitrullinated protein/peptide antibodies (ACPAs) and IgM rheumatoid factors during the course of rheumatoid arthritis and their differential correlation with markers of the acute-phase response. These findings add to a growing body of evidence highlighting the distinct nature of these two autoantibody systems and the role of ACPAs as a disease-specific marker of rheumatoid arthritis.
Comment on
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Different properties of ACPA and IgM-RF derived from a large dataset: further evidence of two distinct autoantibody systems.Arthritis Res Ther. 2009;11(3):R75. doi: 10.1186/ar2704. Epub 2009 May 21. Arthritis Res Ther. 2009. PMID: 19460147 Free PMC article.
References
-
- Rönnelid J, Wick MC, Lampa J, Lindblad S, Nordmark B, Klareskog L, van Vollenhoven RF. Longitudinal analysis of citrullinated protein/peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis: anti-CP status predicts worse disease activity and greater radiological progression. Ann Rheum Dis. 2005;64:1744–1749. doi: 10.1136/ard.2004.033571. - DOI - PMC - PubMed
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- Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, Saigo K, Morinobu A, Koshiba M, Kuntz KM, Kamae I, Kumagai S. Meta-analysis: diagnostic accuracy of anticyclicncitrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146:797–808. - PubMed
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