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Editorial
. 2009;11(5):125.
doi: 10.1186/ar2786. Epub 2009 Sep 14.

Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems

Editorial

Anticitrullinated protein/peptide antibodies and rheumatoid factors: two distinct autoantibody systems

Guido Valesini et al. Arthritis Res Ther. 2009.

Abstract

In a previous issue of Arthritis Research and Therapy, Ursum and colleagues report the relative stabilities of anticitrullinated protein/peptide antibodies (ACPAs) and IgM rheumatoid factors during the course of rheumatoid arthritis and their differential correlation with markers of the acute-phase response. These findings add to a growing body of evidence highlighting the distinct nature of these two autoantibody systems and the role of ACPAs as a disease-specific marker of rheumatoid arthritis.

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References

    1. Ursum J, Bos WH, Stadt RJ van de, Dijkmans BAC, van Schaardenburg D. Different properties of ACPA and IgM-RF derived from a large dataset: further evidence of two distinct autoanti-body systems. A cohort study. Arthritis Res Ther. 2009;11:R75. doi: 10.1186/ar2704. - DOI - PMC - PubMed
    1. Rönnelid J, Wick MC, Lampa J, Lindblad S, Nordmark B, Klareskog L, van Vollenhoven RF. Longitudinal analysis of citrullinated protein/peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis: anti-CP status predicts worse disease activity and greater radiological progression. Ann Rheum Dis. 2005;64:1744–1749. doi: 10.1136/ard.2004.033571. - DOI - PMC - PubMed
    1. Nishimura K, Sugiyama D, Kogata Y, Tsuji G, Nakazawa T, Kawano S, Saigo K, Morinobu A, Koshiba M, Kuntz KM, Kamae I, Kumagai S. Meta-analysis: diagnostic accuracy of anticyclicncitrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med. 2007;146:797–808. - PubMed
    1. Avouac J, Gossec L, Dougados M. Diagnostic and predictive value of anti cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review. Ann Rheum Dis. 2006;65:845–851. doi: 10.1136/ard.2006.051391. - DOI - PMC - PubMed
    1. Vossenaar ER, Després N, Lapointe E, Heijden A van der, Lora M, Senshu T, van Venrooij WJ, Ménard HA. RA specific anti-Sa antibodies target citrullinated vimentin. Arthritis Res Ther. 2004;6:R142–R150. doi: 10.1186/ar1149. - DOI - PMC - PubMed