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Review
. 2009 Oct 1;361(14):1376-85.
doi: 10.1056/NEJMra0807633.

Maternal and neonatal herpes simplex virus infections

Lawrence Corey  1 , Anna Wald
Affiliations
Review

Maternal and neonatal herpes simplex virus infections

Lawrence Corey et al. N Engl J Med. .

Erratum in

  • N Engl J Med. 2009 Dec 31;361(27):2681
No abstract available

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Conflict of interest statement

Conflict of Interest

Dr. Corey is director of the University of Washington Virology Division, which has received grant support from GlaxoSmithKline, a company that make antiviral drugs for the treatment of HSV-2. Dr. Corey receives no salary support from these studies. He is a consultant for Aicuris, which is developing a drug for treating HSV infection. Dr. Corey is a co-inventor on several patents describing antigens/epitopes to which T cell responses to HSV-2 are directed. These proteins have the potential to be utilized in candidate HSV vaccines.

Dr. Wald has received grant support from the National Institutes of Health, GlaxoSmithKline, Antigenics and Astellas. She has been a consultant for Aicuris and Medigene, as well as a speaker for Merck Vaccines. No other potential conflict of interest relevant to this article is reported.

Figures

Figure 1
Figure 1
Pathogenesis of Neonatal Herpes
Figure 2
Figure 2. Risk of Neonatal HSV Among 40,023 Women with Genital Cultures for HSV at Delivery
The data are adapted from Brown et al.
See this image and copyright information in PMC

Comment in

References

    1. Genital Herpes: CDC Fact Sheet. Centers for Disease Control and Prevention; 2007. [Accessed July 8, 2008]. http://www.cdc.gov/std/herpes/STDFact-herpes.htm.
    1. Morris SR, Bauer HM, Samuel MC, Gallagher D, Bolan G. Neonatal herpes morbidity and mortality in California, 1995–2003. Sex Transm Dis. 2008;35:14–8. - PubMed
    1. Whitley R, Davis EA, Suppapanya N. Incidence of neonatal herpes simplex virus infections in a managed-care population. Sex Transm Dis. 2007;34:704–8. - PubMed
    1. Brown ZA, Wald A, Morrow RA, Selke S, Zeh J, Corey L. Effect of serologic status and cesarean delivery on transmission rates of herpes simplex virus from mother to infant. JAMA. 2003;289:203–9. - PubMed
    1. Meissner HC, Reef SE, Cochi S. Elimination of rubella from the United States: a milestone on the road to global elimination. Pediatrics. 2006;117:933–5. - PubMed

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