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Review
. 2009 Oct;102(10):415-24.
doi: 10.1258/jrsm.2009.090221.

An alternative approach to medical genetics based on modern evolutionary biology. Part 3: HERVs in diseases

Frank P Ryan  1
Affiliations
Review

An alternative approach to medical genetics based on modern evolutionary biology. Part 3: HERVs in diseases

Frank P Ryan. J R Soc Med. 2009 Oct.
No abstract available

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Figures

Figure 1
Figure 1
HERV-15 recombination between Y chromosomes during meiosis, leading to deletion or duplication of AZFa genetic domain
See this image and copyright information in PMC

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References

    1. Ryan FP. An alternative approach to medical genetics based on modern evolutionary biology. Part 2: retroviral symbiosis. J R Soc Med 2009;102:324–31 - PMC - PubMed
    1. Roossinck MJ. Symbiosis versus competition in plant virus evolution. Nat Rev Microbiol 2005;3:917–24 - PubMed
    1. Sun C, Skaletsky H, Rozen S, et al. Deletion of azoospermia factor a (AZFa) region of human Y chromosome caused by recombination between HERV15 proviruses. Hum Mol Genet 2000;9:2291–6 - PubMed
    1. Bosch E, Jobling MA. Duplications of the AZFa region of the human Y chromosome are mediated by homologous recombination between HERVs and are compatible with male fertility. Hum Mol Genet 2003;12:341–7 - PubMed
    1. Kamp C, Hirschmann P, Voss H, et al. Two long homologous retroviral sequence blocks in proximal Yq11 cause AZFa microdeletions as a result of intrachromosomal recombination events. Hum Mol Genet 2000;9:2563–72 - PubMed

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