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Review
. 2009 Oct;102(10):415-24.
doi: 10.1258/jrsm.2009.090221.

An alternative approach to medical genetics based on modern evolutionary biology. Part 3: HERVs in diseases

Frank P Ryan  1
Affiliations
Review

An alternative approach to medical genetics based on modern evolutionary biology. Part 3: HERVs in diseases

Frank P Ryan. J R Soc Med. 2009 Oct.
No abstract available

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Figures

Figure 1
Figure 1
HERV-15 recombination between Y chromosomes during meiosis, leading to deletion or duplication of AZFa genetic domain
See this image and copyright information in PMC

References

    1. Ryan FP. An alternative approach to medical genetics based on modern evolutionary biology. Part 2: retroviral symbiosis. J R Soc Med 2009;102:324–31 - PMC - PubMed
    1. Roossinck MJ. Symbiosis versus competition in plant virus evolution. Nat Rev Microbiol 2005;3:917–24 - PubMed
    1. Sun C, Skaletsky H, Rozen S, et al. Deletion of azoospermia factor a (AZFa) region of human Y chromosome caused by recombination between HERV15 proviruses. Hum Mol Genet 2000;9:2291–6 - PubMed
    1. Bosch E, Jobling MA. Duplications of the AZFa region of the human Y chromosome are mediated by homologous recombination between HERVs and are compatible with male fertility. Hum Mol Genet 2003;12:341–7 - PubMed
    1. Kamp C, Hirschmann P, Voss H, et al. Two long homologous retroviral sequence blocks in proximal Yq11 cause AZFa microdeletions as a result of intrachromosomal recombination events. Hum Mol Genet 2000;9:2563–72 - PubMed

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